Gloria Manzotti

Role: Born in Montecchio Emilia (RE) on 13 May 1984, I graduated in Medical Biotechnologies at the University of Modena and Reggio Emilia in 2008. During my thesis intership, I spent three months at the Kimmel Cancer Center at the Thomas Jefferson University (Philadelphia, USA) to study an alternatively spliced form of the transcription factor c-Myb and its role on proliferation and survival ability of p210BCR/ABL-expressing cells, a model of Chronic Myeloid Leukemia.

I obtained my PhD in Clinical and Experimental Medicine at the University of Modena and Reggio Emilia in 2012, with a research that extended and completed my Master degree thesis project. Subsequently, I won a three-years fellowship from AIRC (Associazione Italiana per la Ricerca sul Cancro) for a project concerning the study of the transcription factor C/EBPα as a potential therapeutic tool in Myeloid Leukemia. The study also aimed to identify small molecules able to mimic the biological effects of C/EBPα by using a Drug Repurposing approach.

Since 2015, I am a post-doctoral researcher at the ASMN Research Hospital in Reggio Emilia, where I work in the Cancer Biology and Functional Genomics unit of the Laboratory of Translational Research.

My research activity is focused on the study of non-coding DNA regulatory regions that regulate the expression of the trasncription factor RUNX2, in different type of solid tumors. I am also investigating the interplay between RUNX2 and HDACs. Understanding the mechanisms whereby RUNX2 is aberrantly reactivated during oncogenic transformation will provide new insights into pathways controlling aggressiveness of several types of solid tumors and may be a useful information to design innovative therapeutic approches.

E-mail: manzotti.gloria@ausl.re.it

Scientific Publications