Pubblicazioni

• Tosato, M., Gandini, A., Happel, S., Bas, M., Donzella, A., Zenoni, A., Salvini, A., Andrighetto, A., Di Marco, V. and Asti, M. Chromatographic separation of silver-111 from neutron-irradiated palladium target: toward direct labeling of radiotracers. EJNMMI radiopharm. chem. 8, 43 (2023). https://doi.org/10.1186/s41181-023-00232-0
• Franchi, S., Asti, M., Di Marco, V. et al. The Curies’ element: state of the art and perspectives on the use of radium in nuclear medicine. EJNMMI radiopharm. chem. 8, 38 (2023). https://doi.org/10.1186/s41181-023-00220-4
• Development of Stable Amino-Pyrimidine-Curcumin Analogs: Synthesis, Equilibria in Solution, and Potential Anti-Proliferative Activity. Mari M, Boniburini M, Tosato M, Rigamonti L, Cuoghi L, Belluti S, Imbriano C, Avino G, Asti M, Ferrari E. Int J Mol Sci. 2023 Sep 11;24(18):13963. doi: 10.3390/ijms241813963
• Tosato M, Franchi S, Dalla Tiezza M, Orian L, Gyr T, Alker A, Zanoni G, Pastore P, Andrighetto A, Köster U, Jensen M, Mäcke H, Asti M, Di Marco V. Tuning the Framework of Thioether-Functionalized Polyazamacrocycles: Searching for a Chelator for Theranostic Silver Radioisotopes. Inorg Chem. 2023 Sep 28. doi: 10.1021/acs.inorgchem.3c02456
• Tosato M, Asti M. Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods. Pharmaceuticals (Basel). 2023 Jun 26;16(7):929. doi: 10.3390/ph16070929
• Tosato M, Franchi S, Isse AA, Del Vecchio A, Zanoni G, Alker A, Asti M, Gyr T, Di Marco V, Mäcke H. Is Smaller Better? Cu2+/Cu+ Coordination Chemistry and Copper-64 Radiochemical Investigation of a 1,4,7-Triazacyclononane-Based Sulfur-Rich Chelator. doi.org/10.1021/acs.inorgchem.3c00621
• Capponi PC, Mari M, Ferrari E, Asti M. Radiolabeled Chalcone Derivatives as Potential Radiotracers for β-Amyloid Plaques Imaging. Molecules, 2023, Apr 4;28(7):3233. doi: 10.3390/molecules28073233.
• L. Morselli, A. Donzella, A. Arzenton, M. Asti, S. Bortolussi, S. Corradetti, G. D’Agostino, M. Di Luzio, M. Ferrari, A. Gandini, M. Lunardon, V. Villa, A. Salvini, L. Zangrando, A. Zenoni, A. Andrighetto. Production and characterization of 111Ag radioisotope for medical use in a TRIGA Mark II nuclear research reactor. Appl Radiat Isot. 2023 Jul;197:110798. doi.org/10.1016/j.apradiso.2023.110798
• Tosato M, Asti M, Di Marco V, Jensen ML, Schell J, Dang TT, Köster U, Jensen M, Hemmingsen L. Towards in vivo applications of 111Ag perturbed angular correlation of γ-rays (PAC) spectroscopy. Appl Radiat Isot. 2022 Dec;190:110508. doi: 10.1016/j.apradiso.2022.110508. Epub 2022 Oct 13. PMID: 36283328.
• Mari M, Carrozza D, Malavasi G, Venturi E, Avino G, Capponi PC, Iori M, Rubagotti S, Belluti S, Asti M, Ferrari E. Curcumin-Based β-Diketo Ligands for Ga3+: Thermodynamic Investigation of Potential Metal-Based Drugs. Pharmaceuticals (Basel). 2022 Jul 12;15(7):854. doi: 10.3390/ph15070854. PMID: 35890151; PMCID: PMC9321647.
• Tosato M, Verona M, Favaretto C, Pometti M, Zanoni G, Scopelliti F, Cammarata FP, Morselli L, Talip Z, van der Meulen NP, Di Marco V, Asti M. Chelation of Theranostic Copper Radioisotopes with S-Rich Macrocycles: From Radiolabelling of Copper-64 to In Vivo Investigation. Molecules. 2022 Jun 28;27(13):4158. doi: 10.3390/molecules27134158. PMID: 35807404; PMCID: PMC9268100.
• Tosato M, Pelosato M, Franchi S, Isse AA, May NV, Zanoni G, Mancin F, Pastore P, Badocco D, Asti M and Di Marco V. When ring makes the difference: coordination properties of Cu2+/Cu+ complexes with sulfur-pendant polyazamacrocycles for radiopharmaceutical applications. New J. Chem., 2022,46, 10012-10025
• Asti, M; D’Ambrosio, L; Di Iorio, V; Ferrari, M; Filice, A; Gorgoni, G; Maccauro, M; Pettinato, C; Stasi, M; Zorz, A; Methods for preparation and administration of lutetium-177 oxodotreotide 3.7 GBq: proceedings from an Italian advisory board. Clinical and Translational Imaging. 2021, 9(4), 277-280. doi10.1007/s40336-021-00431-2
• Mari M, Carrozza D, Ferrari E, Asti M. Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry. Int J Mol Sci. 2021 Jul 10;22(14):7410.
• Topical L-Ascorbic Acid Formulation for a Better Management of Non-Melanoma Skin Cancer: Perspective for Treatment Strategies. Pier Cesare Capponi, Domenico Murri and Carmine Pernice. Pharmaceutics 2021, 13, 1201.
• Pernice C, Murri D, Valli R, Crocetta FM, Iori M, Asti M, Ghidini A, Capponi PC Complete response of cutaneous SCC to topical treatment with ascorbic acid solution: A case report.. Clin Case Rep. 2021 Jan 9;9(3):1060-1065.
• Verona M, Rubagotti S, Croci S, Sarpaki S, Borgna F, Tosato M, Vettorato E, Marzaro G, Mastrotto F, Asti M. Preliminary Study of a 1,5-Benzodiazepine-Derivative Labelled with Indium-111 for CCK-2 Receptor Targeting. Molecules 2021, 26, 918.
• Ballan M, Tosato M, Verona M, Caeran M, Borgna F, Vettorato E, Corradetti S, Zangrando L, Sgaravatto M, Verlato M, Asti M, Marzaro G, Mastrotto F, Di Marco V, Maniglio D, Bisio A, Motta A, Quaranta A, Zenoni A, Pastore P, Realdon N, Andrighetto A. Preliminary evaluation of the production of non-carrier added 111Ag as core of a therapeutic radiopharmaceutical in the framework of ISOLPHARM_Ag experiment. Appl Radiat Isot. 2020 Oct;164:109258. doi: 10.1016/j.apradiso.2020.109258. Epub 2020 Jul 6.Appl Radiat Isot. 2020. PMID: 32819502
• Tosato M, Asti M, Dalla Tiezza M, Orian L, Häussinger D, Vogel R, Köster U, Jensen M, Andrighetto A, Pastore P, Marco VD. Highly Stable Silver(I) Complexes with Cyclen-Based Ligands Bearing Sulfide Arms: A Step Toward Silver-111 Labeled Radiopharmaceuticals. Inorg Chem. 2020 Aug 3;59(15):10907-10919. doi: 10.1021/acs.inorgchem.0c01405. Epub 2020 Jul 13.Inorg Chem. 2020. PMID: 32658468 
• Orteca G, Sinnes JP, Rubagotti S, Iori M, Capponi PC, Piel M, Rösch F, Ferrari E, Asti M. Gallium-68 and scandium-44 labelled radiotracers based on curcumin structure linked to bifunctional chelators: Synthesis and characterization of potential PET radiotracers. J Inorg Biochem. 2019;204:110954. doi: 10.1016/j.jinorgbio.2019.110954.
• Croci S, Manicardi A, Rubagotti S, Bonacini M, Iori M, Capponi PC, Cicoria G, Parmeggiani M, Salvarani C, Versari A, Corradini R, Asti M. 64Cu and fluorescein labeled anti-miRNA peptide nucleic acids for the detection of miRNA expression in living cells. Sci Rep. 2019 Mar 4;9(1):3376. 
• Orteca G, Pisaneschi F, Rubagotti S, Liu TW, Biagiotti G, Piwnica-Worms D, Iori M, Capponi PC, Ferrari E, Asti M. Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies. Molecules. 2019 Feb 12;24(3).  doi: 10.3390/molecules24030644
• Giulia Orteca, Francesco Tavanti, Zuzana Bednarikova, Zuzana Gazova, Giovanna Rigillo, Carol Imbriano, Valentina Basile, Mattia Asti, Luca Rigamonti, Monica Saladini, Erika Ferrari, Maria Cristina Menziani. Curcumin derivatives and Aβ-fibrillar aggregates: An interactions’ study for diagnostic/therapeutic purposes in neurodegenerative diseases. Bioorganic and medicinal Chemistry. https://doi.org/10.1016/j.bmc.2018.07.027
• Sollini M, Sghedoni R, Erba P A, Cavuto S, Froio A, De Berti G, Pisanello A, Fraternali A, Iori M, Iaccarino C, Iori M, Asti M, Filice A, Versari A. Diagnostic performances of [18f]fluorocholine positron emission tomography in brain tumors.  Q J Nucl Med Mol Imaging. 2018;62(2):209-2019 Epub 2016 Jan 1. PubMedID: 26329494 
• Luca Rigamonti, Giulia Orteca, Mattia Asti, Valentina Basile, Carol Imbriano, Monica Saladini and Erika Ferrari. New curcumin-derived ligands and their affinity towards Ga3+, Fe3+ and Cu2+: spectroscopic studies on complex formation and stability in solution. New Journal of Chemistry. DOI: 10.1039/C8NJ00535D
• Rubagotti S, Croci S, Ferrari E, Orteca G, Iori M, Capponi PC, Versari A, Asti M. Uptake of Ga-curcumin derivatives in different cancer cell lines: Toward the development of new potential 68Ga-labelled curcuminoids-based radiotracers for tumour imaging. J Inorg Biochem. 2017 May 10;173:113-119.
• Michele Iori, Pier C. Capponi, Sara Rubagotti, Luca Rosario Esposizione, Johanna Seemann, Riccardo Pitzschler, Thorsten Dreger, Debora Formisano, Elisa Grassi, Federica Fioroni, Annibale Versari, Mattia Asti.  Labelling of 90 Y- and 177 Lu-DOTA-Bioconjugates for Targeted Radionuclide Therapy: A Comparison among Manual, Semiautomated, and Fully Automated Synthesis. Contrast Media & Molecular Imaging 2017(7):1-12
• The influence of coping strategies and behavior on the physiological response to socialstress in women: The role of age and menstrual cyclephase. Villada C, Espin L, Hidalgo V, Rubagotti S, Sgoifo A, Salvador A. Physiol Behav. 2016 Dec IF 3,021
• Rubagotti S, Croci S, Ferrari E, Iori M, Capponi PC, Lorenzini L, Calzà L, Versari A, Asti M. Affinity of (nat/68)Ga-Labelled Curcumin and Curcuminoid Complexes for β-Amyloid Plaques: Towards the Development of New Metal-Curcumin Based Radiotracers. Int J Mol Sci. 2016 Sep 6;17(9).
• Skin dose saving of the staff in 90Y/177Lu peptide receptor radionuclide therapy with the automatic dosedispenser. Fioroni F1, Grassi E, Giorgia C, Sara R, Piccagli V, Filice A, Mostacci D, Versari A, Iori. M. Nucl Med Commun. 2016 May 23. IF 1,534
• Asti M, Iori M, Capponi PC, Rubagotti S, Fraternali A, Versari A. Development of a simple kit-based method for preparation of pharmaceutical-grade 68Ga-DOTATOC. Nucl Med Commun. 2015 May;36(5):502-10.
• Riedinger A, Avellini T, Curcio A, Asti M, Xie Y, Tu R, Marras S, Lorenzoni A, Rubagotti S, Iori M, Capponi PC, Versari A, Manna L, Seregni E, Pellegrino T. Post-Synthesis Incorporation of (64)Cu in CuS Nanocrystals to Radiolabel Photothermal Probes: A Feasible Approach for Clinics. J Am Chem Soc. 2015 Dec 9;137(48):15145-51. 
• Asti M, Ferrari E, Croci S, Atti G, Rubagotti S, Iori M, Capponi PC, Zerbini A, Saladini M, Versari A. Synthesis and Characterization of (68)Ga-Labeled Curcumin and Curcuminoid Complexes as Potential Radiotracers for Imaging of Cancer and Alzheimer's Disease.  Inorganic Chemistry 2014;53(10):4922-33
• Ferrari E, Benassi R, Sacchi S, Pignedoli F, Asti M, Saladini M. Curcumin derivatives as metal-chelating agents with potential multifunctional activity for pharmaceutical applications.  J. Inorg. Biochem. 2014;139:38-48.
• Asti M, Iori M, Capponi PC, Atti G, Rubagotti S, Martin R, Brennauer A, Müller M, Bergmann R, Erba PA, Versari A. Influence of different chelators on the radiochemical properties of a 68-Gallium labelled bombesin analogue. Nucl Med Biol. 2014 Jan;41(1):24-35.
• Versari A, Sollini M, Frasoldati A, Fraternali A, Filice A, Froio A, Asti M, Fioroni F, Cremonini N, Putzer D, Erba PA. Differentiated Thyroid Cancer: A New Perspective with Radiolabeled Somatostatin Analogues for Imaging and Treatment of Patients. Thyroid. 2013 Nov 14.
• Sollini M, Farioli D, Froio A, Chella A, Asti M, Boni R, Grassi E, Roncali M, Versari A, Erba PA. Brief report on the use of radiolabeled somatostatin analogs for the diagnosis and treatment of metastatic small-cell lung cancer patients. J Thorac Oncol. 2013 Aug;8(8):1095-101
• Cardiovascular Events and Intensity of Treatment in PolycythemiaVera Marchioli R, Finazzi G, Specchia G, Cacciola R, Cavazzina R, Cilloni D,DeStefano V,Elli E,IurloA, Latagliata R, Lunghi F, Lunghi M, Marfisi RM,MustoP, Masciulli A, Musolino C, Cascavilla N,QuartaG, Randi ML, RapezziD,Ruggeri M, Rumi E,Scortechini AR, Santini S, Scarano M, Siragusa S,SpadeaA, Tieghi A, Angelucci E, Visani G, Vannucchi AM, Barbui T; CYTO-PV Collaborative Group (Merli F, Imovilli A,Codeluppi K, Rubagotti S,..). NEW ENGL J MED 2013 Jan IF 33,921
• Ferrari E, Asti M, Benassi R, Pignedoli F, Saladini M. Metal Binding ability of Curcumin derivatives: theoretical vs experimental approach. Dalton Trans 2013, 42 (15), 5280 – 5289
• Asti M, Atti G, Iori M, Farioli D, Filice A, Versari A. Semiautomated labelling and fractionation of yttrium-90 and lutetium-177 somatostatin analogues using disposable syringes and vials. Nuc Med Commun 2012;33(11):1144-52
• A. Filice, A. Fraternali, M. Asti, E.Grassi, L. Massi, M. Sollini, A. Froio, P.A. Erba, A. Versari. Radiolabeled Somatostatin analogue therapy in advanced neuroendocrine tumors: A single centre experience. Journal of Oncology 01/2012; 2012:320,198
• Asti M, Iori M, Erba PA, Atti G, Farioli D, Guidotti C, Versari A. Radiosynthesis of 68Ga-labelled DOTA-biocytin (68Ga-r-BHD) and assessment of its pharmaceutical quality for clinical use. Nuc Med Commun 2012;33(11):1179-87
• Mattia Asti, Matteo Tegoni, Daniela Farioli, Michele Iori, Claudio Guidotti, Cathy S. Cutler, Pat Mayer, Annibale Versari, Diana Salvo. “Influence of cations on the complexation yield of DOTATATE with yttrium and lutetium: a perspective study for enhancing the 90Y and 177Lu labeling conditions”. Nucl Med Biol 2012;39(4):509-17
• Sghedoni R; Grassi E; Fioroni F; Asti M; Piccagli V; Versari A; Iori M. “Personnel exposure in labelling and administration of 177Lu-DOTA-D-Phe1-Tyr3-octreotide”. Nucl Med Com 2011;32(10):947-953
• Versari A, Camellini L, Carlinfante G, Frasoldati A, Nicoli F, Grassi E, Gallo C, Giunta FP, Fraternali A, Salvo D, Asti M, Azzolini F, Iori V, Sassatelli R. “Ga-68 DOTATOC PET, endoscopic ultrasonography, and multidetector CT in the diagnosis of duodenopancreatic neuroendocrine tumors: a single-centre retrospective study.” Clin Nucl Med. 2010 May;35(5):321-8.
• Mattia Asti; Daniela Farioli; Michele Iori; Claudio Guidotti; Annibale Versari; Diana Salvo “Efficient automated one-step synthesis of 2-[18F]fluoroethylcholine for clinical imaging: optimized reaction conditions and improved quality controls of different synthetic approaches” Nucl. Med. Biol. 2010;37(3):309-315 
• Elisa Grassi, Roberto Sghedoni, Mattia Asti, Federica Fioroni, Diana Salvo and Giovanni Borasi. “Radiation protection in 90-yttrium-labelled DOTA-D-Phe1-Tyr3-octreotide preparations” Nucl Med Com  2009;30(2):176-182  
• M. Asti, G. De Pietri, A. Fraternali, E. Grassi, R. Sghedoni, F. Fioroni, F. Roesch, A. Versari, D. Salvo “ Validation of  68Ge/68Ga generator processing by chemical purification for routine clinical application of  68Ga-DOTATOC ” Nucl. Med. Biol. 2008;35(6):721-725
• M. Asti, E. Grassi, R. Sghedoni, G. De Pietri, F.Fioroni, A. Versari “ Purification by ozonolysis of 18O enriched water after cyclotron irradiation and utilization of the purified water for the production of [18F]-FDG “ Applied Radiation and Isotopes 2007 (65) 831-835
• Mattia Asti, Roberto Cammi, Daniele Cauzzi, Claudia Graiff, Roberto Pattacini, Giovanni Predieri, Alessandro Stercoli, and Antonio Tiripicchio “ On the Reaction of Ph2 PNHPPh2 with RNCS (R =Et,Ph,p -NO2 C6 H4 ): Preparation of the Zwitterionic Ligand EtNHC(S)Ph2 P =NPPh2 C(S)NEt and the Zwitterionic Metalate [(SNS)Rh(CO)] ” Chem. Eur. J. 2005 (11) pag.3413-3419

Libri

• Mattia Asti, Michele Iori, Pier Cesare Capponi e Rubagotti Sara. Radiopharmaceuticals for Treatment of NETs. Chapter 17 in Clinical Applications of Nuclear Medicine Targeted Therapy. Editors: Bombardieri, E., Seregni, E., Evangelista, L., Chiesa, C., Chiti, A. (Eds.)
• Mattia Asti, Valentina di Iorio. Radiofarmaci per terapia. Chapter 15 in Compendio di Radiochimica e Radiofarmacia. Edizioni Minerva Medica s.p.a.

Brevetti

• PCT/IT2020/000039 - MICROWAVE DEVICE FOR THE RAPID LABELLING OF IN KIT-FORMULATED RADIOPHARMACEUTICALS 
• SINTESI DEI DERIVATI DELLA CURCUMINA CON UN GRUPPO CHELANTE PER LA COMPLESSAZIONE DEI METALLI E RADIONUCLIDI, n. 102018000002279 - 17/03/2020
• ITUA20163207 - PREPARAZIONE IN KIT DI RADIOFARMACI MARCATI CON GALLIO-68 Appl.No 201800002279, IT - 31.07.2019  
• NUOVO USO DELL’ACIDO ASCORBICO, N. 102018000010985 11/12/2018