Non-oncological studies in Transfusion Medicine and Regenerative Medicine

Non-oncology research covers various areas such as blood component donation and production processes, transfusion therapies and regenerative medicine with platelet concentrates.

1. Donation: We conduct biochemical and epidemiological studies on the safe and effective donation of blood components, as well as on the preservation of red blood cells and platelets. In collaboration with the Qualitative Research Unit and local Volunteer Organizations, we study strategies to actively engage individuals from ethnic groups with rare phenotypes (e.g., Sub-Saharan Africa) in blood donation, in order to provide optimal care for patients with sickle cell disease.
2. Transfusion therapies: We carry out biochemical, molecular, and epidemiological studies on major diseases treated in Transfusion Medicine, such as β-thalassemia, sickle cell disease, and polycythemia.
3. Regenerative Medicine: We focus on the biochemical and metabolic characterization of platelet-rich plasma, with particular attention to its ability to effectively repair damaged tissues such as bone and skin. The goal is to investigate the cellular, biochemical, and molecular mechanisms underlying tissue regeneration following treatment with platelet derivatives, in order to generate scientific evidence supporting new therapeutic options.

Ongoing Projects for 2024/2025:

• "Evaluation of the Regenerative Potential of Platelet Concentrates for the Treatment of Hard-to-Heal Skin Ulcers". PI: Davide Schiroli
• "Improving Care for Patients with Sickle Cell Disease: A Multi-Stakeholder Project With and For People of Sub-Saharan African Origin". PI: Luca Ghirotto, Co-PI: Chiara Marraccini