SYNTHESIS OF CURCUMIN DERIVATIVES WITH A CHELATING GROUP FOR THE COMPLEXITY OF METALS AND RADIONUCLIDES

CATEGORY

C07D
 

AVAILABILITY

available
 

PATENT PHASE

Recognised patent on date 17/03/2020
 

INVENTOR

Dr. Mattia Asti – Manager of Radiopharmaceuticals Unit
Dr. Pier Cesare Capponi – no longer pertaining to the Authority
Dr. Michele Iori – Radiopharmaceuticals Unit
Dr. Sara Rubagotti – no longer pertaining to the USL-IRCCS-RE
 

FIELD OF INTEREST

New molecules used as precursors for radiopharmaceuticals for the diagnosis of cancer and Alzheimer’s disease and related complexes with radioactive and other metals.

DESCRIPTION

A compound obtained from the reaction between a metal-chelating agent and a curcuminoid (i.e. curcumin or a derivative thereof) is described. The invention also relates to the use of such compound for preparing a complex with at least one radioactive or non-radioactive metal through a complexation reaction of the compound with said metal. The complex thus obtained is used for the diagnosis or treatment of diseases, in particular cancer and Alzheimer’s disease.

HOLDER

AUSL-IRCCS with registered office in Via Amendola n. 2 in Reggio Emilia
Sold to third parties on 30 May 2019.
 

DOCUMENTS

Patent certificate n. 102018000002279